Minimal Change Disease (MCD): Morphology

  1. Lipoid necrosis
  2. Foot process disease
  3. Nil disease

Gross appearance:
  1. Kidneys are of normal size and shape

Microscopic appearance:
  1. Light microscopy: Normal glomeruli, Lipid in tubules
  2. Electron microscopy: Podocyte foot process effacement, No deposits
  3. Fluorescence microscopy: Negative (no complement/Ig deposits)

What do you see? What do you feel?
Creative Commons License